|T000073, NUDT15 Tracer (MM95)
Compound Image

T000073

NUDT15 Tracer (MM95)

  • Description

    Formula:

    C39H37BF2N8O6S

    avg. MolWt:

    794.65 u

    PAINS elements:

    none detected

    SMILES:

    display
  • Properties

    Store at:

    -80 °C

    Absorption:

    450 nm

    Emission:

    590 nm

    clogP:

    4.21
  • References

    Contributing Lab:

    Knapp Lab, University of Frankfurt

  • Experimental

    Assay window 10.3
    \(Z'\) 0.82
    CP agreement yes
    Tracer titration

    \(K_\mathrm{D}^{\,\mathrm{app}}\):

    > 10 µM
    titration curve
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    TH1760

    \(\mathrm{EC}_{50}\):

    170 nM
    displacement curve
    raw data

    Comment: NLuc-NUDT15

    Assay window 43.5
    \(Z'\) 0.91
    CP agreement yes
    Tracer titration

    \(K_\mathrm{D}\):

    166 nM
    titration curve
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    TH1760

    \(\mathrm{IC}_{50}\):

    43 nM
    displacement curve
    raw data

    Comment: NLuc-NUDT15