|T000053, Propranolol Tracer
Compound Image

T000053

Propranolol Tracer

  • Description

    Formula:

    C43H47BF2N6O6

    avg. MolWt:

    792.69 u

    PAINS elements:

    none detected

    SMILES:

    display
  • Properties

    Store at:

    -80 °C

    Absorption:

    450 nm

    Emission:

    590 nm

    clogP:

    4.66
  • References

    Synthesis:

    Publication

    Contributing Lab:

    Promega Corp., Madison

  • Experimental

    Assay window 1.6
    \(Z'\) 0.8
    CP agreement yes
    Tracer titration

    \(K_\mathrm{D}^{\,\mathrm{app}}\):

    135 nM
    titration curve
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    Propranolol

    \(\mathrm{EC}_{50}\):

    20 nM
    displacement curve
    raw data

    Comment: HiBiT-ADRB1

    Reference: PMID

    Assay window 2.4
    \(Z'\) 0.9
    CP agreement yes
    Tracer titration

    \(K_\mathrm{D}^{\,\mathrm{app}}\):

    16 nM
    titration curve
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    Propranolol

    \(\mathrm{EC}_{50}\):

    4 nM
    displacement curve
    raw data

    Comment: HiBiT-ADRB2

    Reference: PMID