|T000001, IAP Tracer

Compound Image

T000001

IAP Tracer

Description

Formula:

C₄₈H₅₉BF₂N₈O₇S

avg. MolWt:

940.92 u

PAINS elements:

none detected

SMILES:

display

Properties

Store at:

-80 °C

Absorption:

450 nm

Emission:

590 nm

clogP:

5.65
References

Synthesis:

Publication

Contributing Lab:

Promega Corp., Madison and Knapp Lab, University of Frankfurt
Experimental

Assay window 7.0

\(Z'\) 0.6

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

17 nM

raw data

Tracer displacement

i

Compound used for displacement:

LCL161

\(\mathrm{EC}_{50}\):

5 nM

raw data

Reference: PMID

Assay window 8.0

\(Z'\) 0.7

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

163 nM

raw data

Tracer displacement

i

Compound used for displacement:

LCL161

\(\mathrm{EC}_{50}\):

15 nM

raw data

Reference: PMID

Assay window 10.8

\(Z'\) 0.7

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

240 nM

raw data

Tracer displacement

i

Compound used for displacement:

LCL161

\(\mathrm{EC}_{50}\):

26 nM

raw data

Reference: PMID

Assay window 42.9

\(Z'\) 0.8

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

2713 nM

raw data

Tracer displacement

i

Compound used for displacement:

LCL161

\(\mathrm{EC}_{50}\):

212 nM

raw data

Reference: PMID

Assay window 4.3

\(Z'\) 0.6

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

38 nM

raw data

Tracer displacement

i

Compound used for displacement:

LCL161

\(\mathrm{EC}_{50}\):

15 nM

raw data

Reference: PMID